The PGA Screen
Sep 26 2018No images attached
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Review Details
Protein product name
The PGA Screen
Research area
Developmental biology
Company
Molecular Dimensions
Product code
MD1-50
Batch
008-1-50
protein subcategory
Protein Crystallisation Screening
Year
2016
Sensitivity
Price value
Ease of use
Followed instructions
true
Friendliness protocol
Results quality
Reproducibility
Product rating
Figure Legend
Further Information
The PGA screen is one of those containing "exotic" conditions for protein crystallization, allowing the exploration of non-conventional chemistries in the crystallization phase diagram. We use it routinely and found that, in some cases such as in our latest publication (doi: 10.1038/s41467-018-05631-5), initial crystal hits could only be obtained using PGA as crystallization agent.
Dear Prof. Forneris, Thank you very much for your kind words! PGAs have high nucleation potential so can be used at lower concentrations than traditional precipitants. This makes them particularly powerful for easily precipitating proteins. Yours Claire