The PGA Screen

Sep 26 2018
by Federico Forneris Register or Log in to message the reviewer onsite.

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Review Details

Protein product name

The PGA Screen

Research area

Developmental biology

Company

Molecular Dimensions

Product code

MD1-50

Batch

008-1-50

Protein subcategory

Protein Crystallisation Screening

Year

2016

NH and/or COOH modification

Purity

Experiment type

Product webpage

Protein stability

Price value

Results quality

Reproducibility

Product rating

Figure Legend

Further Information

The PGA screen is one of those containing "exotic" conditions for protein crystallization, allowing the exploration of non-conventional chemistries in the crystallization phase diagram. We use it routinely and found that, in some cases such as in our latest publication (doi: 10.1038/s41467-018-05631-5), initial crystal hits could only be obtained using PGA as crystallization agent.

Comments

Claire Naylor Sep 27 2018

Dear Prof. Forneris, Thank you very much for your kind words! PGAs have high nucleation potential so can be used at lower concentrations than traditional precipitants. This makes them particularly powerful for easily precipitating proteins. Yours Claire